February 20, 2006 at 6:34 PM EST - Updated July 26 at 9:52 PM
Victoria Claflin Woodhull 1st U.S. Female Presidential Candidate
Victoria Claflin Woodhull becomes the first woman presidential candidate in the United States when she is nominated by the National Radical Reformers.
Susanna Medora Salter 1st Female Mayor
Susanna Medora Salter becomes the first woman elected mayor of an American town, in Argonia, Kansas.
Jeannette Rankin 1st Female Congresswoman
Jeannette Rankin, of Montana, is the first woman to be elected to the U.S. House of Representatives.
Nellie Tayloe Ross 1st Female State Governor
Nellie Tayloe Ross becomes the first woman to serve as governor of a state, in Wyoming. In the fall of 1924 she was elected to succeed her deceased husband, William Bradford Ross. (Miriam Amanda "Ma" Ferguson is inaugurated governor of Texas days later.)
Hattie Wyatt Caraway 1st Female Senator
Hattie Wyatt Caraway, of Arkansas, becomes the first woman elected to the U.S. Senate.
Frances Perkins 1st Female on a Presidential Cabinet
Frances Perkins is appointed secretary of labor by President Franklin D. Roosevelt, making her the first woman member of a presidential cabinet.
Oveta Culp Hobby 1st Female Secretary of Health, Education & Welfare
Oveta Culp Hobby becomes the first woman to serve as Secretary of Health, Education, and Welfare. She is also the first director of the Women's Army Auxiliary Corps (WAAC), and the first woman to receive the U.S. Army Distinguished Service Medal.
Margaret Chase Smith 1st Female Presidential Nominee (by a major party)
Margaret Chase Smith, of Maine, becomes the first woman nominated for president of the United States by a major political party, at the Republican National Convention in San Francisco.