EMS responded to a crash that occurred about 1:50 p.m. at the 99 mile marker on I-75.
One vehicle was overturned at the scene.
According to officials, one of the two passengers was airlifted to a hospital in Macon for their severe injuries. The other passenger suffered moderate injuries and was taken to Crisp Regional in Cordele.
The identities of the victims and cause of the accident is still unknown.