Valdosta Police drug agents found meth lab at 1207 Gornto Road Thursday.
They say people inside were cooking meth when agents kicked in the door to serve a warrant about five o'clock.
They shut down Gornto Road, evacuated four nearby homes, and called in a hazmat team.
Those neighbors were allowed back in their homes a few hours later, but the clean up crews were still working and the road remained closed late Thursday night.
Three people who were renting the home will be charged with manufacturing meth.