The Eagles gave the Knights a battle in the first half before Deerfield-Windsor pulls away for a 68-49 win.
Reggie Brown led the Knights with 18 points.
Deerfield-Windsor is 16-1 and on the road for a region game Friday night at Calvary Christian in Columbus.
In other high school scores, Brookwood boys beat Byne 67-41 and the Brookwood girls win 56-35 over the Lady Saints.
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