Drew Kelley spotted the Bearcats with a first inning lead on a three-run homerun.
The Trojans came back to win game one 7-3 and take game two in five innings 11-1.
Lee County will host Westside-Macon next Friday in the region playoffs.
If the Trojans win the best 2-3 series, they will be region champions.
In the GISA, Deerfield-Windsor blanks Westfield 10-0.
The win moves the Knights in sole possession of first place in GISA 3-AAA.
Evan Boyd retired the first 16 batters he faced before giving up back to back singles in the sixth.
Deerfield-Windsor still has to beat Brookwood Tuesday in Thomasville to clinch another region title.
In Class A, Terrell Academy hits six homeruns in a 15-9 region win at Randolph-Southern.